Clinical Trials

There is an encouraging amount of research being undertaken which is directed at Myositis. In Australia there are a number of clinical trials which are underway, recruiting or awaiting ethics approval. See www.anzctr.org.au for details.

Also see the website of The Myositis Association in the USA – www.myositis.org which has a list of clinical trials being conducted in the USA. Of recent importance is recruitment in the USA for a trial for a drug for treating polymyositis and dermatomyositis.

Australian Clinical Trials in brief :

1. Completed – an extension study.

An extension study of the Efficacy, Safety and Tolerability of Bimagrumab – BYM 338 on physical function, muscle strength and mobility in IBM patients who previously participated in the core study in NSW, WA and Vic.

2. Recruiting
Dysphagia (swallowing) problems in patients with myositis. Sir Charles Gardiner Hospital – Nedlands WA Contact Dr. Claire Langdon.

3. Recruiting by invitation
To explore the new form of resistance training (Kaatsu) in reducing disability caused by IBM.  Sir Charles Gardiner Hospital – Nedlands WA. Contact: Mr. Dave Hawthorn 08 93462337

4. Not yet recruiting.
Pilot study prior to Phase 1 trial to study the treatment of patients with IBM with Triheptanoin. Concord hospital NSW Contact : Assoc Prof Alistair Corbett.

5. Active Not recruiting.

Testosterone plus exercise to improve muscle strength and performance in men with IBM.

Prof Merrilee Needham – Institute for Immunology and Infectious Diseases, Murdoch University

6. Active but not recruiting.

Ketogenic Diet in Inclusion Body Myositis – single patient trial.

Dr Matthew Phillips, Neurology Dept, Waikato Hospital, New Zealand.

7, Active, not recruiting.

Trial to evaluate the efficacy and safety of Abatacept in combination with standard therapy compared to standard therapy alone in improving disease activity in Adults with active Idiopathic Inflammatory Myopathy. Sites in NSW, QLD and WA and overseas. Sponsor is Bristol Myers Squibb